Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.30 |
| ▸ | CNR1 | P21554 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8279385 | 0.97 | ACE (0.42) | ACEMMECNR2 | |
| SCHEMBL8280285 | 0.93 | ACE (0.43) | ACEMME | |
| SCHEMBL8280295 | 0.93 | ACE (0.43) | ACEMME | |
| SCHEMBL8280287 | 0.87 | ACE (0.38) | ACEMME | |
| SCHEMBL8358947 | 0.85 | ACE (0.53) | ACEMME | |
| SCHEMBL8280288 | 0.85 | ACE (0.36) | ACEMME | |
| SCHEMBL13815133 | 0.78 | ACE (0.46) | ACEMME | |
| SCHEMBL8278667 | 0.78 | ACE (0.33) | ACEMME | |
| SCHEMBL13815134 | 0.76 | ACE (0.47) | ACEMME | |
| SCHEMBL8279386 | 0.72 | MME (0.30) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692157-B1 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE | VERTEX PHARMA (US) | 2013-04-17 | — | — | EP | disclosed |