Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.53 |
| ▸ | MME | P08473 | 3/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8279385 | 0.88 | ACE (0.42) | ACEMME | |
| SCHEMBL14865487 | 0.85 | ACE (0.41) | ACEMME | |
| SCHEMBL7713379 | 0.85 | ACE (0.56) | ACEMMERENLMNAHSD17B10 | |
| SCHEMBL8280295 | 0.84 | ACE (0.43) | ACEMME | |
| SCHEMBL8280285 | 0.84 | ACE (0.43) | ACEMME | |
| SCHEMBL22175815 | 0.81 | ACE (0.53) | ACEMMEREN | |
| SCHEMBL22175774 | 0.78 | ACE (0.46) | ACEMMERENLMNAHSD17B10 | |
| SCHEMBL3729224 | 0.78 | ACE (0.60) | ACEMME | |
| SCHEMBL8280287 | 0.78 | ACE (0.38) | ACEMME | |
| SCHEMBL645665 | 0.77 | ACE (0.63) | ACEMMEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509330-B2 | Angiotensin converting enzyme (ACE); neutral endopeptidase (NEP); containing a dipeptide derived from an amino acid, or a conformationally restricted dipeptide mimic | BRISTOL-MYERS SQUIBB COMPANY | 2003-01-21 | — | — | US | disclosed |