Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 20/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 1/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 1/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 1/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 1/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 1.00 |
| ▸ | RXRB | P28702 | 8/20 | 0.73 |
| ▸ | RXRG | P48443 | 8/20 | 0.73 |
| ▸ | RARB | P10826 | 6/20 | 0.73 |
| ▸ | RARG | P13631 | 5/20 | 0.73 |
| ▸ | RARA | P10276 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22560751 | 0.89 | RXRA (0.81) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14874176 | 0.87 | RXRA (0.77) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1073921 | 0.86 | RXRA (0.76) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| Bexarotene SCHEMBL29412584 | 0.85 | RXRA (1.00) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12181009 | 0.85 | RXRA (0.79) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| Bexarotene SCHEMBL9025 | 0.85 | RXRA (1.00) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| Bexarotene SCHEMBL5322954 | 0.85 | RXRA (1.00) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL12755164 | 0.85 | RXRA (0.79) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2594347 | 0.84 | RXRA (0.73) | RXRAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL31758293 | 0.84 | RXRA (0.73) | RXRAHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140235676-A1 | RXR AGONIST COMPOUNDS AND METHODS | UNIV CASE WESTERN RESERVE (US) | 2014-08-21 | — | — | US | disclosed |
| WO-2013056232-A2 | RXR AGONISTS COMPOUNDS AND METHODS | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-04-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235676-A1 | RXR AGONIST COMPOUNDS AND METHODS | RXRA, RXRB, RXRG | RXRA 1/4885HDAC3 890/4885HDAC4 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.