Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 5/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14874864 | 1.00 | GPR119 (0.64) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL14874816 | 0.99 | GPR119 (0.65) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL14874892 | 0.98 | GPR119 (0.65) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL3489560 | 0.89 | GPR119 (0.75) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL3487835 | 0.89 | GPR119 (0.75) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL14874904 | 0.88 | GPR119 (0.66) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL3488858 | 0.88 | GPR119 (0.76) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL3489287 | 0.88 | GPR119 (0.77) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL14874971 | 0.86 | GPR119 (0.63) | GPR119ALDH1A1KMT2AMEN1ALOX15 | |
| SCHEMBL14874928 | 0.86 | GPR119 (0.79) | GPR119ALDH1A1KMT2AMEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111107-B1 | HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS | METABOLEX INC (US) | 2013-04-24 | — | — | EP | claimed |