Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 7/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.54 |
| ▸ | KIF11 | P52732 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | XRCC6 | P12956 | 1/20 | 0.46 |
| ▸ | XRCC5 | P13010 | 1/20 | 0.46 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14877134 | 0.90 | KIF11 (0.47) | PRKDCPIK3CDPIK3CBKIF11FGFR1 | |
| SCHEMBL14877438 | 0.89 | KIF11 (0.49) | PRKDCPIK3CDPIK3CBKIF11FGFR1 | |
| SCHEMBL14877399 | 0.85 | PDGFRB (0.56) | KIF11FGFR1FLT1PDGFRBKDR | |
| SCHEMBL14877217 | 0.83 | PRKDC (0.48) | PRKDCPIK3CDPIK3CBKIF11FGFR1 | |
| SCHEMBL14877387 | 0.83 | FGFR1 (0.53) | PRKDCPIK3CDPIK3CBKIF11FGFR1 | |
| SCHEMBL7668851 | 0.77 | KDM4E (0.58) | PRKDCPIK3CDKIF11PIK3CAKDM4E | |
| SCHEMBL14877015 | 0.75 | KIF11 (0.46) | KIF11FGFR1FLT1PDGFRBKDR | |
| SCHEMBL14877166 | 0.74 | KIF11 (0.47) | KIF11FGFR1FLT1PDGFRBKDR | |
| SCHEMBL14876948 | 0.73 | KIF11 (0.44) | PRKDCKIF11FGFR1FLT1PDGFRB | |
| SCHEMBL15389029 | 0.72 | KIF11 (0.46) | PRKDCKIF11FGFR1PDGFRBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045437-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-06-02 | — | — | US | disclosed |
| US-9006239-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2015-04-14 | — | — | US | disclosed |
| US-8710064-B2 | 2-aryl-4-quinazolinones and their pharmaceutical compositions | CHINA MEDICAL UNIVERSITY (TW) | 2014-04-29 | — | — | US | disclosed |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2014-01-16 | — | — | US | disclosed |
| US-20130310376-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CHINA MEDICAL UNIVERSITY (TW) | 2013-11-21 | — | — | US | disclosed |
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | CHINA MEDICAL UNIVERSITY (TW) | 2013-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102602-A1 | 2-Aryl-4-Quinazolinones And Their Pharmaceutical Compositions | AQP4, KRAS, RB1 | PRKDC 4606/4885PIK3CD 2974/4885PIK3CB 3362/4885 |
| US-20130310376-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CCNE2, NFE2, NR2E1 | PRKDC 4749/4885PIK3CD 3561/4885PIK3CB 4104/4885 |
| US-20140018363-A1 | 2-ARYL-4-QUINAZOLINONES AND THEIR PHARMACEUTICAL COMPOSITIONS | CCNE2, RB1, NR2E1 | PRKDC 4740/4885PIK3CD 3738/4885PIK3CB 4024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.