Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.63 |
| ▸ | NPC1 | O15118 | 8/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAPDH | P04406 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15255707 | 0.85 | RAB9A (0.63) | RAB9ANPC1MAPTSMN1; SMN2HPGD | |
| SCHEMBL1430419 | 0.84 | MAPT (0.67) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1888991 | 0.82 | MAPT (0.69) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13613088 | 0.80 | RAB9A (0.58) | RAB9ANPC1MAPTSMN1; SMN2HPGD | |
| SCHEMBL12236808 | 0.79 | RAB9A (0.65) | RAB9ANPC1MAPTSMN1; SMN2HPGD | |
| SCHEMBL12213910 | 0.79 | RAB9A (0.56) | RAB9ANPC1MAPTSMN1; SMN2HPGD | |
| SCHEMBL5803752 | 0.78 | MAPT (0.65) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL172042 | 0.78 | MAPT (0.65) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL171882 | 0.78 | MAPT (0.70) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL15427115 | 0.77 | MAPT (1.00) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426359-B2 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-23 | — | — | US | disclosed |