Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cephalothin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.98 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.98 |
| ▸ | HPGD | P15428 | 3/20 | 0.98 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.98 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.98 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.98 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.98 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.98 |
| ▸ | POLB | P06746 | 3/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.82 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 2/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.82 |
| ▸ | GLA | P06280 | 1/20 | 0.82 |
| ▸ | APEX1 | P27695 | 1/20 | 0.82 |
| ▸ | PKM | P14618 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cephalothin SCHEMBL10974577 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL16072835 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL2990 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL9159686 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL4394024 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL11039891 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL4319851 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL5791156 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL1624515 | 0.99 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL1331925 | 0.98 | MAPT (0.98) | MAPTTDP1NR1I2HPGDCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2857 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250312046-A1 | LIGATION CLIP AND PREPARATION METHOD THEREOF | SICHUAN GUONA TECHNOLOGY CO., LTD. (CN) | 2025-10-09 | — | — | US | claimed |
| EP-4628110-A1 | LIGATING CLIP | Chengdu Guona Technology Co., Ltd (CN) | 2025-10-08 | — | — | EP | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-117982740-B | Absorbable biomedical polymer material, ligature clip and preparation method | 四川国纳科技有限公司 | 2024-07-12 | — | — | CN | claimed |
| US-20240173512-A1 | METHODS FOR POTENTIATING ANTIMICROBIAL AGENTS | STREETERVILLE CAPITAL, LLC | 2024-05-30 | — | — | US | claimed |
| CN-117982740-A | Absorbable biomedical polymer material, ligature clip and preparation method | 四川国纳科技有限公司 | 2024-05-07 | — | — | CN | claimed |
| CN-117959321-A | Rutin with effect of inhibiting escherichia coli efflux pump | 河北农业大学 | 2024-05-03 | — | — | CN | claimed |
| CN-117924238-A | Synthesis method of cefalotin sodium intermediate 2-thiopheneacetyl chloride | 成都化润药业有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-114657208-B | Method for establishing spider-flavor transgenic hairy root genetic transformation system | 云南中医药大学 | 2024-02-13 | — | — | CN | claimed |
| US-11890421-B2 | Methods for potentiating antimicrobial agents | BEYOND AIR LTD (IL) | 2024-02-06 | — | — | US | claimed |
| US-4486411-A | SYNERGISTIC MIXTURES WITH BETA-LACTAM ANTIBIOTICS | PFIZER INC. (US) | 1984-12-04 | — | — | US | claimed |
| US-4264730-A | Medium for determining sensitivity of Klebsiella and Enterobacter organisms to selected antibiotics | MCDONNELL DOUGLAS CORPORATION (US) | 1981-04-28 | — | — | US | claimed |
| US-4132848-A | Method of preparing a rapidly dissolving powder of crystalline cephalothin sodium for parenteral administration | ELI LILLY AND COMPANY (US) | 1979-01-02 | — | — | US | claimed |
| US-4122158-A | FOR TREATMENT OF BURNS; BIODEGRADABLE HYDROPHOBIC POLYMER; SUSTAINED RELEASE | ALZA CORPORATION (US) | 1978-10-24 | — | — | US | claimed |
| US-4104391-A | Method of preparing stable sterile ampoules of crystalline cephalosporins for parenteral administration | ELI LILLY AND COMPANY (US) | 1978-08-01 | — | — | US | claimed |
| US-4029655-A | Method of preparing stable sterile crystalline cephalosporins for parenteral administration | ELI LILLY AND COMPANY (US) | 1977-06-14 | — | — | US | claimed |
| US-4024871-A | POLYURETHANE | ETHICON, INC. (US) | 1977-05-24 | — | — | US | claimed |
| US-3987797-A | ANTIMICROBIAL SUTURES | ETHICON, INC. (US) | 1976-10-26 | — | — | US | claimed |
| US-3983209-A | HYDROPHOBIC BIOERODIBLE POLYMER, MICROBIOCIDE OR PROTEOLYTIC ENZYME | ALZA CORPORATION (US) | 1976-09-28 | — | — | US | claimed |
| US-3937655-A | Method for preparing stable β-lactam-type-antibiotic susceptibility test discs | ELI LILLY AND COMPANY (US) | 1976-02-10 | — | — | US | claimed |