Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 15/20 | 0.75 |
| ▸ | RAB9A | P51151 | 15/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 13/20 | 0.75 |
| ▸ | LMNA | P02545 | 6/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.75 |
| ▸ | RELA | Q04206 | 3/20 | 0.75 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12749634 | 0.86 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL14881192 | 0.83 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1747973 | 0.83 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL5023461 | 0.83 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1819335 | 0.82 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL3278505 | 0.77 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL1752748 | 0.76 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL30576765 | 0.76 | DHODH (0.60) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL26606436 | 0.76 | DHODH (0.60) | NPC1RAB9ASMN1; SMN2LMNANFKB1 | |
| SCHEMBL31744868 | 0.76 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013056679-A1 | NOVEL HETEROARYL-AMINO DERIVATIVES | BEIJING HANMI PHARMACEUTICAL CO., LTD (CN) | 2013-04-25 | — | — | WO | disclosed |