Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1284466 | 0.88 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 | |
| SCHEMBL1283969 | 0.85 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 | |
| SCHEMBL1623248 | 0.80 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 | |
| SCHEMBL19715929 | 0.79 | P2RY12 (0.40) | PIK3CAKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL16921199 | 0.79 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 | |
| SCHEMBL1283966 | 0.78 | LMNA (0.49) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 | |
| SCHEMBL16924704 | 0.76 | MEN1 (0.56) | PIK3CAKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL17881272 | 0.76 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 | |
| SCHEMBL1284141 | 0.76 | PIK3CA (0.43) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 | |
| SCHEMBL1284560 | 0.75 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBHDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. | 2013-04-25 | — | — | US | disclosed |
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. | 2013-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | KRAS, HRAS, KSR2 | PIK3CA 31/4885PIK3CD 194/4885PIK3CB 156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.