Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599331 | 0.88 | SIGMAR1 (0.47) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL1804589 | 0.88 | SIGMAR1 (0.47) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL1804586 | 0.88 | SIGMAR1 (0.47) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL1804581 | 0.88 | SIGMAR1 (0.47) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL1804582 | 0.88 | SIGMAR1 (0.47) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL14889370 | 0.81 | CHRM4 (0.45) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL14889367 | 0.81 | CHRM4 (0.45) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL14889371 | 0.81 | CHRM4 (0.45) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL14889369 | 0.81 | CHRM4 (0.45) | CHRM4DRD2DRD3SIGMAR1LMNA | |
| SCHEMBL2597989 | 0.81 | SIGMAR1 (0.52) | CHRM4DRD2DRD3SIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432783-B1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LAB (US) | 2013-05-01 | — | — | EP | disclosed |