Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TKT | P29401 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11817206 | 0.98 | DPP4 (0.45) | DPP4SMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL3080426 | 0.79 | KMT2A (0.49) | DPP4SMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL4464844 | 0.78 | DPP4 (0.59) | DPP4LMNAMAPK1MEN1KMT2A | |
| SCHEMBL25066775 | 0.75 | LMNA (0.46) | DPP4SMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL9821280 | 0.75 | LMNA (0.43) | DPP4SMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL4461787 | 0.74 | DPP4 (0.59) | DPP4SMN1; SMN2LMNAATMNPC1 | |
| SCHEMBL18381563 | 0.73 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL31515074 | 0.73 | KMT2A (0.49) | DPP4SMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL14951416 | 0.73 | KMT2A (0.49) | DPP4SMN1; SMN2LMNAALDH1A1ATM | |
| SCHEMBL31515073 | 0.73 | KMT2A (0.49) | DPP4SMN1; SMN2LMNAALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3151818-A1 | COMPOSITIONS AND METHODS OF TREATING DIABETIC RETINOPATHY | Case Western Reserve University (US) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015187942-A1 | COMPOSITIONS AND METHODS OF TREATING DIABETIC RETINOPATHY | CASE WESTERN RESERVE UNIVERSITY (US) | 2015-12-10 | — | — | WO | disclosed |
| WO-2013063269-A2 | COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-05-02 | — | — | WO | disclosed |