Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14167186 | 0.92 | ALOX5 (0.41) | EPHX1ALOX5 | |
| SCHEMBL14895039 | 0.80 | EPHX1 (0.54) | EPHX1ALOX5 | |
| SCHEMBL28527546 | 0.77 | EPHX1 (0.46) | EPHX1ALOX5 | |
| SCHEMBL5927975 | 0.75 | EPHX1 (0.61) | EPHX1 | |
| SCHEMBL5927952 | 0.73 | EPHX1 (0.65) | EPHX1 | |
| SCHEMBL5927948 | 0.73 | EPHX1 (0.65) | EPHX1 | |
| SCHEMBL29177034 | 0.72 | EPHX1 (0.52) | EPHX1ALOX5 | |
| SCHEMBL14895043 | 0.72 | EPHX1 (0.42) | EPHX1 | |
| SCHEMBL5928140 | 0.70 | EPHX1 (0.46) | EPHX1ALOX5 | |
| Hydrochloric Acid SCHEMBL3213524 | 0.69 | DPP4 (0.42) | EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771327-A1 | NOVEL PYRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2014-09-03 | — | — | EP | disclosed |
| WO-2013060751-A1 | NOVEL PYRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2013-05-02 | — | — | WO | disclosed |