Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.44 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | HRH2 | P25021 | 3/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14895185 | 0.86 | HRH4 (0.40) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL14895169 | 0.85 | HRH4 (0.64) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL14895429 | 0.85 | HRH3 (0.64) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL14895187 | 0.85 | HRH4 (0.43) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL14895240 | 0.83 | HRH4 (0.65) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL26129799 | 0.80 | OPRK1 (0.39) | OPRK1 | |
| SCHEMBL14895109 | 0.78 | HRH4 (0.63) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL14895282 | 0.77 | HRH4 (0.59) | HRH4HRH3HRH1KCNH2HRH2 | |
| SCHEMBL14895236 | 0.76 | OPRK1 (0.39) | OPRK1MAP4K4 | |
| SCHEMBL14828930 | 0.76 | HRH4 (0.36) | HRH4OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013060881-A1 | PYRIDOPYRIMIDINES AND THEIR THERAPEUTIC USE | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2013-05-02 | — | — | WO | disclosed |