Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 11/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 4/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5158094 | 0.93 | ACVRL1 (0.48) | ACVRL1METRIPK1 | |
| SCHEMBL14313162 | 0.92 | ACVRL1 (0.56) | ACVRL1METNTRK1NTRK2THRB | |
| SCHEMBL5077600 | 0.90 | ACVRL1 (0.49) | ACVRL1METRIPK1 | |
| SCHEMBL14313175 | 0.88 | ACVRL1 (0.42) | ACVRL1METPIK3CD | |
| SCHEMBL14313032 | 0.88 | ACVRL1 (0.43) | ACVRL1METPIK3CD | |
| SCHEMBL5074881 | 0.87 | ACVRL1 (0.46) | ACVRL1METRIPK1PIK3CD | |
| SCHEMBL14314307 | 0.87 | ACVRL1 (0.41) | ACVRL1METPIK3CD | |
| SCHEMBL14313055 | 0.86 | ACVRL1 (0.50) | ACVRL1METRIPK1 | |
| SCHEMBL14312757 | 0.84 | ACVRL1 (0.61) | ACVRL1METRIPK1 | |
| SCHEMBL5080438 | 0.83 | ACVRL1 (0.49) | ACVRL1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431695-B2 | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-30 | — | — | US | disclosed |
| US-8431695-B2 | Pyrrolo[2,1-f][1,2,4]triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-04-30 | — | — | US | disclosed |