Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13301203 | 1.00 | EPHX2 (0.42) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL14898572 | 1.00 | EPHX2 (0.42) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL14898566 | 1.00 | EPHX2 (0.42) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL14898568 | 1.00 | EPHX2 (0.42) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL14898567 | 1.00 | EPHX2 (0.42) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL14898565 | 1.00 | EPHX2 (0.42) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL14898570 | 1.00 | EPHX2 (0.42) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL11301771 | 0.93 | CHRNB2 (0.40) | EPHX2MAPTDNM1CHRNB2CHRNB4 | |
| SCHEMBL14870601 | 0.84 | MAPT (0.42) | EPHX2MAPTDNM1LMNAALDH1A1 | |
| SCHEMBL6895698 | 0.84 | MAPT (0.42) | EPHX2MAPTDNM1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431576-B2 | Heterocyclic compounds for the treatment of neurological and psychological disorders | ALKERMES PHARMA IRELAND LIMITED (IE) | 2013-04-30 | — | — | US | disclosed |