Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MIF | P14174 | 6/20 | 0.50 |
| ▸ | CD74 | P04233 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2544422 | 0.85 | MAPT (0.53) | TP53MAPTLMNATSHRHTT | |
| SCHEMBL2546842 | 0.83 | MAPT (0.50) | TP53MAPTLMNATSHRHTT | |
| SCHEMBL14563242 | 0.82 | MAPT (0.62) | TP53MAPTMIFCD74POLB | |
| SCHEMBL2546874 | 0.82 | MAPT (0.49) | TP53MAPTLMNATSHRHTT | |
| SCHEMBL12241021 | 0.81 | MIF (0.53) | TP53MAPTMIFCD74POLB | |
| SCHEMBL16419129 | 0.78 | MIF (0.57) | TP53MAPTLMNATSHRHTT | |
| SCHEMBL16421403 | 0.78 | MIF (0.57) | TP53MAPTMIFCD74POLB | |
| SCHEMBL20595111 | 0.76 | MIF (0.54) | TP53MAPTLMNATSHRSMN1; SMN2 | |
| SCHEMBL2546995 | 0.74 | MAPT (0.49) | TP53MAPTMIFCD74POLB | |
| SCHEMBL24885166 | 0.73 | ALDH1A1 (0.56) | TP53LMNATSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431572-B2 | 2-oxo-3-benzylbenzoxazol-2-one derivatives and related compounds as met kinase inhibitors for the treatment of tumours | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-04-30 | — | — | US | disclosed |