Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.64 |
| ▸ | FAM20C | Q8IXL6 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | TXK | P42681 | 1/20 | 0.59 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 2/20 | 0.58 |
| ▸ | INSR | P06213 | 1/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.58 |
| ▸ | TEK | Q02763 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 3/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.57 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116462 | 0.83 | IGF1R (0.79) | IGF1RFAM20CLYNEGFRINSR | |
| SCHEMBL1575673 | 0.82 | IGF1R (0.59) | IGF1RFAM20CEGFRINSRMET | |
| SCHEMBL6976694 | 0.82 | EGFR (0.81) | IGF1RFAM20CROCK1EGFRINSR | |
| SCHEMBL6981464 | 0.82 | IGF1R (0.78) | IGF1RFAM20CLYNEGFRINSR | |
| SCHEMBL1575537 | 0.81 | IGF1R (0.63) | IGF1RFAM20CROCK1EGFRINSR | |
| SCHEMBL1575060 | 0.81 | IGF1R (0.58) | IGF1RFAM20CLYNTXKSYK | |
| SCHEMBL17260972 | 0.80 | ROCK1 (0.70) | LYNTXKSYKROCK1KDR | |
| SCHEMBL6979115 | 0.80 | FAM20C (0.70) | IGF1RFAM20CSYKEGFRINSR | |
| SCHEMBL6976835 | 0.80 | IGF1R (0.78) | IGF1RFAM20CROCK1EGFRINSR | |
| SCHEMBL6641667 | 0.79 | JAK3 (0.65) | IGF1RLYNTXKSYKROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431589-B2 | 2,4-diaminopyrimidine derivatives | NOVARTIS AG (CH) | 2013-04-30 | — | — | US | disclosed |