Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 14/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 14/20 | 0.54 |
| ▸ | MLYCD | O95822 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899169 | 0.81 | NR1H2 (0.50) | NR1H2NR1H3MLYCD | |
| SCHEMBL14899173 | 0.80 | NR1H2 (0.49) | NR1H2NR1H3MLYCD | |
| SCHEMBL14899177 | 0.80 | MLYCD (0.48) | NR1H2NR1H3MLYCD | |
| SCHEMBL14899171 | 0.79 | NR1H3 (0.54) | NR1H2NR1H3MLYCD | |
| SCHEMBL6212908 | 0.72 | MLYCD (0.55) | NR1H2NR1H3MLYCD | |
| SCHEMBL4875544 | 0.70 | MLYCD (0.64) | NR1H2NR1H3MLYCD | |
| SCHEMBL3235441 | 0.69 | MLYCD (1.00) | MLYCD | |
| SCHEMBL11421053 | 0.69 | NR1H3 (0.62) | NR1H2NR1H3MLYCD | |
| SCHEMBL6493890 | 0.68 | NR1H3 (0.60) | NR1H2NR1H3MLYCD | |
| SCHEMBL4875535 | 0.68 | MLYCD (0.61) | NR1H2NR1H3MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431563-B2 | Compounds that interact with glucokinase regulatory protein for the treatment of diabetes | AMGEN INC. (US) | 2013-04-30 | — | — | US | disclosed |