Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | PEPD | P12955 | 1/20 | 0.31 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14899641 | 0.90 | DPP4 (0.36) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL8270356 | 0.90 | DPP4 (0.36) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL8269752 | 0.90 | DPP4 (0.36) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL14899644 | 0.85 | HDAC4 (0.30) | HDAC4HDAC1 | |
| SCHEMBL8269749 | 0.80 | DPP4 (0.43) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL2434106 | 0.80 | DPP4 (0.43) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL8277771 | 0.80 | DPP4 (0.43) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL15149979 | 0.80 | DPP4 (0.43) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL8276954 | 0.80 | DPP4 (0.43) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL14554067 | 0.80 | DPP4 (0.43) | DPP4DPP8DPP9FAPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44186-E1 | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-30 | — | — | US | disclosed |