Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11944565 | 0.86 | ALDH1A1 (0.40) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL17058044 | 0.84 | MCHR1 (0.39) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL17058354 | 0.84 | MCHR1 (0.38) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL17058290 | 0.83 | MCHR1 (0.41) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL14899793 | 0.83 | MCHR1 (0.43) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL17058463 | 0.80 | POLB (0.39) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL17058486 | 0.79 | MAPT (0.42) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL14899789 | 0.79 | MCHR1 (0.36) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL17057929 | 0.79 | POLB (0.42) | MCHR1NPBWR1SMN1; SMN2POLBLMNA | |
| SCHEMBL14899744 | 0.79 | SMN1; SMN2 (0.47) | MCHR1NPBWR1SMN1; SMN2POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |