Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11945081 | 0.88 | ALDH1A1 (0.57) | SMN1; SMN2POLBLMNAKMT2AMCHR1 | |
| SCHEMBL11945565 | 0.88 | TP53 (0.47) | SMN1; SMN2POLBLMNATP53MCHR1 | |
| SCHEMBL11945215 | 0.88 | MAPT (0.57) | SMN1; SMN2POLBLMNAKMT2ATP53 | |
| SCHEMBL17057929 | 0.88 | POLB (0.42) | SMN1; SMN2POLBLMNATP53MCHR1 | |
| SCHEMBL11944020 | 0.88 | ALDH1A1 (0.56) | SMN1; SMN2POLBLMNAKMT2AMCHR1 | |
| SCHEMBL14899737 | 0.87 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBLMNAKMT2ATP53 | |
| SCHEMBL11944494 | 0.87 | POLB (0.52) | SMN1; SMN2POLBLMNAKMT2AMCHR1 | |
| SCHEMBL11944729 | 0.86 | ALDH1A1 (0.57) | SMN1; SMN2POLBLMNAKMT2AMCHR1 | |
| SCHEMBL11945583 | 0.86 | NPSR1 (0.52) | SMN1; SMN2POLBLMNAKMT2ATP53 | |
| SCHEMBL11944098 | 0.86 | POLB (0.52) | SMN1; SMN2POLBLMNAKMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |