SCHEMBL149055

SCHEMBL149055

COc1ccc(C(=O)c2ccccc2-n2cc(OC(C)=O)c3ccccc32)c(OC)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.47
MAPT P10636 4/20 0.44
MAPK1 P28482 1/20 0.44
LMNA P02545 4/20 0.42
CYP1A2 P05177 2/20 0.42
CYP3A4 P08684 2/20 0.42
CYP2C19 P33261 2/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
TSHR P16473 1/20 0.42
CA12 O43570 1/20 0.41
CA9 Q16790 1/20 0.41
HPGD P15428 2/20 0.41
PGR P06401 1/20 0.41
ADORA3 P0DMS8 1/20 0.41
AR P10275 1/20 0.41
CHRM1 P11229 1/20 0.41
ALOX15 P16050 1/20 0.41
TBXA2R P21731 1/20 0.41
SLC6A2 P23975 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3407920 0.87 LMNA (0.48) NPC1MAPTMAPK1LMNACYP1A2
SCHEMBL16817090 0.85 NPC1 (0.43) NPC1MAPTLMNACYP1A2CYP3A4
SCHEMBL16817091 0.82 HSD17B10 (0.44) NPC1MAPTKMT2AMEN1HPGD
SCHEMBL150147 0.82 MAPK1 (0.49) MAPTMAPK1LMNACYP1A2KMT2A
Phosphoric Acid SCHEMBL151187 0.79 SMN1; SMN2 (0.39) NPC1MAPTLMNACYP1A2CYP3A4
Phosphoric Acid SCHEMBL151189 0.78 NPC1 (0.38) NPC1MAPTLMNACYP1A2CYP3A4
Choline SCHEMBL151186 0.78 NPC1 (0.37) NPC1MAPTLMNACYP1A2CYP3A4
SCHEMBL155943 0.77 SLC5A1 (0.47) NPC1CA12CA9RAB9A
SCHEMBL27872825 0.77 SLC5A1 (0.47) NPC1CA12CA9RAB9A
SCHEMBL155944 0.77 SLC5A1 (0.47) NPC1CA12CA9RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2529025-B1 GROWTH MEDIUM FOR THE DETECTION OF MICROORGANISMS BY FLUORESCENCE ALLYING A FLUOROGENIC SUBSTRATE AND A PH-SENSITIVE FLUOROPHORE EMD MILLIPORE CORP (US) 2015-06-24 EP claimed
EP-2529025-B1 GROWTH MEDIUM FOR THE DETECTION OF MICROORGANISMS BY FLUORESCENCE ALLYING A FLUOROGENIC SUBSTRATE AND A PH-SENSITIVE FLUOROPHORE EMD MILLIPORE CORP (US) 2015-06-24 EP disclosed
US-8940909-B2 Indicator platform BIOSYNTH AG (CH) 2015-01-27 US disclosed
CN-102459168-B novel indicator platform BIOSINT S.P.A. (CH) 2014-10-01 CN disclosed
EP-2427431-B1 NOVEL INDICATOR PLATFORM BIOSYNTH AG (CH) 2013-05-01 EP disclosed
CN-102459168-A Novel indicator platform BIOSYNTH AG 2012-05-16 CN disclosed
EP-2427431-A1 NOVEL INDICATOR PLATFORM Biosynth AG (CH) 2012-03-14 EP disclosed
US-20120058503-A1 Novel Indicator Platform BIOSYNTH AG (CH) 2012-03-08 US disclosed
EP-2256103-A1 Novel indicator platform Biosynth AG (CH) 2010-12-01 EP disclosed
WO-2010128120-A1 NOVEL INDICATOR PLATFORM BIOSYNTH AG (CH) 2010-11-11 WO disclosed