Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 19/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906031 | 0.84 | GRM4 (0.71) | GRM4 | |
| SCHEMBL6922868 | 0.79 | GRM4 (0.70) | GRM4 | |
| SCHEMBL6922917 | 0.78 | GRM4 (1.00) | GRM4 | |
| SCHEMBL14906056 | 0.73 | GRM4 (0.72) | GRM4 | |
| SCHEMBL6923458 | 0.73 | GRM4 (0.70) | GRM4 | |
| SCHEMBL19795233 | 0.72 | GRM4 (0.47) | GRM4 | |
| SCHEMBL19795235 | 0.72 | GRM4 (0.42) | GRM4 | |
| SCHEMBL19794592 | 0.72 | GRM4 (0.71) | GRM4 | |
| SCHEMBL14906241 | 0.71 | GRM4 (0.64) | GRM4 | |
| SCHEMBL14896339 | 0.71 | GRM4 (0.64) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013060029-A1 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK SHARP & DOHME CORP (US) | 2013-05-02 | — | — | WO | disclosed |
| WO-2013063100-A1 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |