Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14907012 | 0.88 | LMNA (0.52) | PIK3CGLMNAMAPTKDM4EECE2 | |
| SCHEMBL14906953 | 0.75 | KDM4E (0.63) | PIK3CGLMNAMAPTKDM4EECE2 | |
| SCHEMBL14906949 | 0.75 | MAPT (0.51) | PIK3CGLMNAMAPTKDM4ECYP1A2 | |
| SCHEMBL14906950 | 0.75 | PIK3CG (0.58) | PIK3CGLMNAMAPTKDM4EHTT | |
| SCHEMBL684718 | 0.74 | PIK3CG (0.84) | PIK3CGLMNAMAPTKDM4ECYP1A2 | |
| SCHEMBL14906947 | 0.74 | GCGR (0.54) | LMNAMAPTKDM4EHTTKMT2A | |
| SCHEMBL14907008 | 0.74 | GCGR (0.55) | LMNAMAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL14907027 | 0.73 | PIK3CG (0.62) | PIK3CGLMNAMAPTKDM4EECE2 | |
| SCHEMBL14907016 | 0.73 | MEN1 (0.53) | PIK3CGLMNAMAPTKDM4EHTT | |
| SCHEMBL14907017 | 0.73 | LMNA (0.56) | LMNAMAPTKDM4ECYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873661-B2 | Small molecule malarial Aldolase-TRAP enhancers and glideosome inhibitors | NEW YORK UNIVERSITY (US) | 2018-01-23 | — | — | US | disclosed |
| US-20140275088-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | THE JOHNS HOPKINS UNIVERSITY | 2014-09-18 | — | — | US | disclosed |
| WO-2013063243-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | NEW YORK UNIVERSITY (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275088-A1 | SMALL MOLECULE MALARIAL ALDOLASE-TRAP ENHANCERS AND GLIDEOSOME INHIBITORS | ALDOA, DERA, TALDO1 | PIK3CG 3964/4885LMNA 1944/4885MAPT 578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.