Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.57 |
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.57 |
| ▸ | HRH1 | P35367 | 4/20 | 0.57 |
| ▸ | HRH2 | P25021 | 3/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14907373 | 0.93 | HRH4 (0.58) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895185 | 0.87 | HRH4 (0.40) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895429 | 0.86 | HRH3 (0.64) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14907402 | 0.85 | HRH4 (0.57) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14907397 | 0.84 | HRH4 (0.59) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14895109 | 0.79 | HRH4 (0.63) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14907381 | 0.79 | HRH4 (0.58) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14907390 | 0.77 | PDE10A (0.39) | HRH4ADORA2AADORA2BPDE10APIK3CD | |
| SCHEMBL14895312 | 0.73 | HRH3 (1.00) | HRH3HRH4KCNH2HRH1HRH2 | |
| SCHEMBL14907386 | 0.73 | ADORA2A (0.38) | HRH4ADORA2AADORA2BPDE10APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013060881-A1 | PYRIDOPYRIMIDINES AND THEIR THERAPEUTIC USE | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2013-05-02 | — | — | WO | disclosed |