Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 2/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.34 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28182603 | 0.84 | KMT2A (0.38) | KMOKDM4EALDH1A1HTTHSD17B10 | |
| SCHEMBL1699267 | 0.80 | NAPRT (0.43) | KMOKDM4EASPHKDM8HTT | |
| SCHEMBL15880100 | 0.79 | HSD17B10 (0.43) | KMOKDM4EALDH1A1ASPHKDM8 | |
| SCHEMBL30613704 | 0.79 | KMO (0.43) | KMOKDM4ESMN1; SMN2ASPHKDM8 | |
| SCHEMBL148901 | 0.79 | AAK1 (0.44) | KMOKDM4EASPHKDM8HTT | |
| SCHEMBL3540937 | 0.79 | KMO (0.43) | KMOKDM4ESMN1; SMN2ASPHKDM8 | |
| SCHEMBL27945025 | 0.75 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2ASPHKDM8 | |
| SCHEMBL23012638 | 0.75 | SLC22A12 (0.39) | KMOASPHSORT1 | |
| SCHEMBL10884107 | 0.75 | TRPV1 (0.46) | KMOHTTHSD17B10CNR2 | |
| SCHEMBL31214548 | 0.75 | MAPT (0.40) | KMOKDM4EALDH1A1SMN1; SMN2ASPH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415358-B | 6-aminopyridin-3-ylthiazoles as ROR gamma t modulators | 詹森药业有限公司 | 2022-04-05 | — | — | CN | disclosed |
| US-8987274-B2 | Macrocycles that increase p53 activity and the uses thereof | MERCK SHARP & DOHME CORP (US) | 2015-03-24 | — | — | US | disclosed |
| US-8987274-B2 | Macrocycles that increase p53 activity and the uses thereof | MERCK SHARP & DOHME CORP (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140315916-A1 | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | MERCK SHARP & DOHME LLC | 2014-10-23 | — | — | US | disclosed |
| US-20140315916-A1 | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | MERCK SHARP & DOHME LLC | 2014-10-23 | — | — | US | disclosed |
| WO-2013062923-A1 | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | MERCK SHARP & DOHME CORP. (US) | 2013-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315916-A1 | MACROCYCLES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF | TP53, MDM2, TP53BP1 | KMO 3807/4885KDM4E 2192/4885ALDH1A1 3320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.