Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 7/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14907891 | 0.84 | GRK6 (0.67) | GRK6MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL18552380 | 0.84 | GRK6 (0.50) | GRK6LMNAMAPTALDH1A1GAA | |
| SCHEMBL17213167 | 0.83 | GRK6 (0.47) | GRK6LMNAALDH1A1GAA | |
| SCHEMBL21763980 | 0.82 | GRK6 (0.49) | GRK6LMNAMAPTALDH1A1HPGD | |
| SCHEMBL17212977 | 0.81 | GRK6 (0.56) | GRK6 | |
| SCHEMBL14907940 | 0.81 | GRK6 (0.65) | GRK6HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17213028 | 0.80 | GRK6 (0.49) | GRK6POLBMEN1KMT2AMAPT | |
| SCHEMBL6405045 | 0.78 | GRK6 (0.60) | GRK6KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL14907758 | 0.77 | GRK6 (0.64) | GRK6SMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL17213064 | 0.75 | GRK6 (0.48) | GRK6CHEK2KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013063458-A2 | INHIBITING G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-02 | — | — | WO | disclosed |