Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 9/20 | 0.56 |
| ▸ | XDH | P47989 | 4/20 | 0.51 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14907891 | 0.89 | GRK6 (0.67) | GRK6 | |
| SCHEMBL17213085 | 0.83 | HSD17B10 (0.41) | GRK6ALOX15HSD17B10 | |
| SCHEMBL14907940 | 0.83 | GRK6 (0.65) | GRK6TYMP | |
| SCHEMBL17213028 | 0.82 | GRK6 (0.49) | GRK6 | |
| SCHEMBL14907758 | 0.82 | GRK6 (0.64) | GRK6ALOX15HSD17B10TYMP | |
| SCHEMBL14907730 | 0.81 | GRK6 (0.71) | GRK6 | |
| SCHEMBL21764068 | 0.80 | GRK6 (0.39) | GRK6ALOX15HSD17B10 | |
| SCHEMBL14907778 | 0.78 | GRK6 (0.67) | GRK6 | |
| SCHEMBL17213125 | 0.76 | GRK6 (0.46) | GRK6XDHPDK1ALOX15 | |
| SCHEMBL6405125 | 0.76 | TYMP (0.60) | GRK6TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015164415-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-10-29 | — | — | WO | disclosed |