Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | GRK6 | P43250 | 8/20 | 0.41 |
| ▸ | APEX1 | P27695 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16171127 | 0.89 | GRK6 (0.41) | GRK6KMT2AALDH1A1TDP1MAPT | |
| SCHEMBL14907786 | 0.81 | GRK6 (0.61) | F2F10PLGPLAUPLAT | |
| SCHEMBL16171092 | 0.81 | ALDH1A1 (0.51) | GRK6KMT2AALDH1A1TDP1MAPT | |
| SCHEMBL17214726 | 0.80 | MAPT (0.43) | KMT2AALDH1A1TDP1MAPK1MAPT | |
| SCHEMBL14907758 | 0.77 | GRK6 (0.64) | GPR35GRK6APEX1ALDH1A1TYMP | |
| SCHEMBL14907829 | 0.77 | GRK6 (0.64) | F2F10PLGPLAUPLAT | |
| SCHEMBL14907723 | 0.76 | GRK6 (0.67) | GRK6APEX1MAPTTHRB | |
| SCHEMBL14907941 | 0.75 | GRK6 (0.64) | GRK6KMT2AALDH1A1TDP1TYMP | |
| SCHEMBL14907883 | 0.75 | GRK6 (0.60) | GRK6KMT2AALDH1A1TDP1MAPT | |
| SCHEMBL14907809 | 0.75 | GRK6 (0.48) | GRK6KMT2AALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015164415-A1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2015-10-29 | — | — | WO | disclosed |
| WO-2013063458-A2 | INHIBITING G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2013-05-02 | — | — | WO | disclosed |