Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Octane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| O-Xylene SCHEMBL27774107 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| Dodecane SCHEMBL28874984 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| Decane SCHEMBL15200902 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| Decane SCHEMBL9863298 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| Hexadecane SCHEMBL9547561 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| O-Xylene SCHEMBL10941793 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| Octane SCHEMBL8046192 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| Nonane SCHEMBL10943433 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| O-Xylene SCHEMBL7635740 | 0.92 | TSHR (0.59) | TSHRACHEP2RX7LIPGALDH1A1 | |
| Octanol SCHEMBL3281086 | 0.91 | ALDH1A1 (0.59) | TSHRACHEP2RX7LIPGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2589428-B1 | SILICA FILM FILTER | NGK INSULATORS LTD (JP) | 2023-07-26 | — | — | EP | disclosed |
| US-9579610-B2 | Method for manufacturing silica membrane filter, and silica membrane filter | NGK INSULATORS, LTD. (JP) | 2017-02-28 | — | — | US | disclosed |
| US-20150053605-A1 | METHOD FOR MANUFACTURING SILICA MEMBRANE FILTER, AND SILICA MEMBRANE FILTER | NGK INSULATORS, LTD. (JP) | 2015-02-26 | — | — | US | disclosed |
| EP-2832428-A1 | METHOD FOR MANUFACTURING SILICA MEMBRANE FILTER, AND SILICA MEMBRANE FILTER | NGK Insulators, Ltd. (JP) | 2015-02-04 | — | — | EP | disclosed |
| US-8764889-B2 | Silica film filter and process for producing silica film filter | NGK INSULATORS, LTD. (JP) | 2014-07-01 | — | — | US | disclosed |
| US-20130112078-A1 | SILICA FILM FILTER AND PROCESS FOR PRODUCING SILICA FILM FILTER | NGK INSULATORS, LTD. (JP) | 2013-05-09 | — | — | US | disclosed |
| EP-2589428-A1 | SILICA FILM FILTER AND PROCESS FOR PRODUCING SILICA FILM FILTER | NGK Insulators, Ltd. (JP) | 2013-05-08 | — | — | EP | disclosed |