Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853118 | 0.78 | MAPT (0.41) | ALPLCA9DRD1CYP1A2GAA | |
| SCHEMBL14910385 | 0.76 | TLR8 (0.42) | ALPLCA9GAAKDM4ENPC1 | |
| SCHEMBL4856665 | 0.76 | ALPL (0.58) | ALPLCA9GAAKDM4ENPC1 | |
| SCHEMBL2088520 | 0.74 | MAP4K4 (0.50) | KCNH2DRD1GAAADORA1 | |
| SCHEMBL2091970 | 0.74 | PARP15 (0.39) | KCNH2ADORA2APPARG | |
| SCHEMBL5305952 | 0.73 | NPC1 (0.41) | ALPLCA9GAAKDM4ENPC1 | |
| SCHEMBL14726304 | 0.73 | NOTUM (0.48) | ALPLCA9GAAKDM4ENPC1 | |
| SCHEMBL1857325 | 0.72 | DRD1 (0.40) | DRD1CYP1A2GAAKDM4ENPC1 | |
| SCHEMBL14910882 | 0.71 | APP (0.31) | — | |
| SCHEMBL1857868 | 0.71 | NPC1 (0.54) | CYP1A2GAAKDM4ENPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118067-B1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SIENA BIOTECH SPA (IT) | 2013-05-08 | — | — | EP | disclosed |