Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 9/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.63 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.63 |
| ▸ | HTR2C | P28335 | 2/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | MLNR | O43193 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.63 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.63 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.63 |
| ▸ | MC3R | P41968 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868488 | 1.00 | CASR (0.63) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| SCHEMBL1491267 | 1.00 | CASR (0.63) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| SCHEMBL6867802 | 0.89 | CASR (0.65) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| SCHEMBL6868109 | 0.87 | CASR (0.63) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| Hydrochloric Acid SCHEMBL1491244 | 0.86 | CASR (0.64) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| SCHEMBL6867188 | 0.84 | CASR (0.45) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| SCHEMBL16143095 | 0.81 | SLC6A4 (0.56) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| SCHEMBL17915496 | 0.79 | CASR (0.87) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| SCHEMBL17053439 | 0.79 | CASR (0.87) | CASRSLC6A4SLC6A2ADRA2CHTR2C | |
| Cinacalcet SCHEMBL29373418 | 0.77 | CASR (1.00) | CASRSLC6A4SLC6A2ADRA2CHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475641-B1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM SPA (IT) | 2013-11-06 | — | — | EP | disclosed |
| EP-2475641-A1 | PROCESS FOR PREPARING CINACALCET | ZaCh System S.p.A. (IT) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011029833-A1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2011-03-17 | — | — | WO | disclosed |