Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 6/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.45 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867694 | 0.85 | CASR (0.45) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL1491263 | 0.84 | CASR (0.63) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL1491267 | 0.84 | CASR (0.63) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL6868488 | 0.84 | CASR (0.63) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL6221120 | 0.79 | SLC6A4 (0.64) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL13965847 | 0.77 | CASR (0.52) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL5473697 | 0.77 | CASR (0.57) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL5473700 | 0.77 | CASR (0.57) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL6868490 | 0.75 | CASR (0.71) | CASRSLC6A4SLC6A2OPRM1DRD3 | |
| SCHEMBL15131364 | 0.72 | CASR (0.49) | CASRSLC6A4SLC6A2OPRM1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011029833-A1 | PROCESS FOR PREPARING CINACALCET | ZACH SYSTEM S.P.A. (IT) | 2011-03-17 | — | — | WO | disclosed |