Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.61 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.61 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.61 |
| ▸ | PRKACA | P17612 | 4/20 | 0.61 |
| ▸ | PRKACG | P22612 | 4/20 | 0.61 |
| ▸ | PRKACB | P22694 | 4/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.61 |
| ▸ | PRKCG | P05129 | 4/20 | 0.61 |
| ▸ | PRKCB | P05771 | 4/20 | 0.61 |
| ▸ | PRKCA | P17252 | 4/20 | 0.61 |
| ▸ | PRKCH | P24723 | 4/20 | 0.61 |
| ▸ | PRKCI | P41743 | 4/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.61 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.61 |
| ▸ | MYLK | Q15746 | 3/20 | 0.61 |
| ▸ | CCR2 | P41597 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491316 | 0.86 | ROCK2 (0.58) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| SCHEMBL16508190 | 0.84 | ROCK2 (0.58) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| SCHEMBL1491292 | 0.84 | ROCK2 (0.66) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| SCHEMBL1761118 | 0.81 | ROCK2 (0.62) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| SCHEMBL1491288 | 0.81 | ROCK2 (0.53) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| SCHEMBL1491299 | 0.79 | PRKCE (0.65) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| Fasudil SCHEMBL18279981 | 0.76 | ROCK2 (0.89) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| Fasudil SCHEMBL29362990 | 0.76 | ROCK2 (1.00) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| Fasudil SCHEMBL29381868 | 0.76 | ROCK2 (1.00) | ROCK2ROCK1CYP3A4PRKCEPRKCD | |
| Fasudil SCHEMBL6269832 | 0.76 | ROCK2 (1.00) | ROCK2ROCK1CYP3A4PRKCEPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2296472-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | Amnestix, Inc. (US) | 2011-03-23 | — | — | EP | claimed |
| WO-2009151845-A9 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2010-01-28 | — | — | WO | claimed |
| WO-2009151845-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2009-12-17 | — | — | WO | claimed |
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. | 2011-12-01 | — | — | US | disclosed |
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. | 2011-12-01 | — | — | US | disclosed |
| EP-2296472-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | Amnestix, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009151845-A9 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2010-01-28 | — | — | WO | disclosed |
| WO-2009151845-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | AMNESTIX, INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294789-A1 | COMPOUNDS FOR RHO KINASE INHIBITION AND FOR IMPROVING LEARNING AND MEMORY | ROCK1, IRAK1, ROCK2 | ROCK2 3/4885ROCK1 1/4885CYP3A4 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.