Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.57 |
| ▸ | EED | O75530 | 4/20 | 0.57 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.47 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.47 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.47 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592576 | 0.85 | EZH2 (0.66) | EZH2EEDSUZ12HDAC1HDAC6 | |
| SCHEMBL14917617 | 0.82 | EZH2 (0.53) | EZH2EEDSUZ12RBBP4RBBP7 | |
| SCHEMBL2593774 | 0.75 | EZH2 (0.74) | EZH2EEDSUZ12HDAC1HDAC6 | |
| SCHEMBL2594119 | 0.73 | EZH2 (0.70) | EZH2EEDSUZ12HDAC1HDAC6 | |
| SCHEMBL14717553 | 0.73 | EZH2 (0.71) | EZH2EEDSUZ12EZH1 | |
| SCHEMBL19620903 | 0.73 | EZH2 (0.69) | EZH2EEDSUZ12HDAC1HDAC6 | |
| SCHEMBL21419362 | 0.73 | EED (1.00) | EZH2EEDSUZ12 | |
| SCHEMBL2596013 | 0.72 | EZH2 (0.61) | EZH2EEDSUZ12HDAC1EZH1 | |
| SCHEMBL19620967 | 0.72 | EZH2 (0.67) | EZH2EEDSUZ12HDAC1HDAC6 | |
| SCHEMBL2592733 | 0.72 | EZH2 (0.58) | EZH2EEDSUZ12HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773754-A1 | METHOD OF TREATMENT | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067296-A1 | METHOD OF TREATMENT | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED (GB) | 2013-05-10 | — | — | WO | disclosed |