Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.53 |
| ▸ | BRD4 | O60885 | 4/20 | 0.51 |
| ▸ | EED | O75530 | 3/20 | 0.51 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.51 |
| ▸ | EZH1 | Q92800 | 3/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.42 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.42 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917618 | 0.82 | EZH2 (0.57) | EZH2EEDSUZ12EZH1RBBP4 | |
| SCHEMBL2592576 | 0.82 | EZH2 (0.66) | EZH2BRD4EEDSUZ12EZH1 | |
| SCHEMBL17956125 | 0.80 | EZH2 (0.64) | EZH2BRD4EEDSUZ12EZH1 | |
| SCHEMBL14717974 | 0.78 | EZH2 (0.55) | EZH2BRD4EEDSUZ12EZH1 | |
| SCHEMBL2594609 | 0.77 | EZH2 (0.75) | EZH2BRD4EZH1BRD2BRD3 | |
| SCHEMBL17956121 | 0.76 | EZH2 (0.52) | EZH2BRD4EEDSUZ12EZH1 | |
| SCHEMBL2595229 | 0.76 | EZH2 (0.66) | EZH2BRD4EZH1BRD2BRD3 | |
| SCHEMBL2592711 | 0.75 | EZH2 (0.75) | EZH2BRD4EEDSUZ12EZH1 | |
| SCHEMBL12180080 | 0.75 | EZH2 (0.76) | EZH2BRD4EEDSUZ12EZH1 | |
| SCHEMBL14726796 | 0.75 | EZH2 (0.66) | EZH2BRD4EZH1BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773754-A1 | METHOD OF TREATMENT | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013067296-A1 | METHOD OF TREATMENT | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (No 2) LIMITED (GB) | 2013-05-10 | — | — | WO | disclosed |