Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 19/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14917837 | 1.00 | LMNA (0.52) | LMNATP53NPSR1L3MBTL1HDAC4 | |
| SCHEMBL444821 | 0.85 | LMNA (0.59) | LMNATP53NPSR1L3MBTL1HDAC4 | |
| SCHEMBL4255186 | 0.82 | LMNA (0.56) | LMNATP53NPSR1L3MBTL1HDAC4 | |
| SCHEMBL14917894 | 0.77 | HDAC4 (0.55) | HDAC4HDAC6HDAC1 | |
| SCHEMBL445772 | 0.75 | LMNA (0.60) | LMNATP53NPSR1L3MBTL1HDAC4 | |
| SCHEMBL14917729 | 0.73 | HDAC4 (0.65) | HDAC4HDAC6HDAC1 | |
| SCHEMBL14918056 | 0.72 | HDAC4 (0.57) | LMNAL3MBTL1HDAC4HDAC6HDAC1 | |
| SCHEMBL14918393 | 0.72 | HDAC4 (0.56) | HDAC4HDAC6HDAC1 | |
| SCHEMBL4247069 | 0.71 | LMNA (0.58) | LMNATP53NPSR1L3MBTL1HDAC4 | |
| SCHEMBL20838108 | 0.71 | HDAC4 (0.83) | HDAC4HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066833-A1 | COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066833-A1 | COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |