SCHEMBL14917871

SCHEMBL14917871

CC[C@@H](COc1ccc(-c2noc(C(F)(F)F)n2)cc1)NC(=O)c1cc2cc(OC3CCOCC3)ccc2o1

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 14/20 0.49
HDAC6 Q9UBN7 12/20 0.47
TAS1R3 Q7RTX0 3/20 0.45
TAS1R1 Q7RTX1 3/20 0.45
HDAC1 Q13547 3/20 0.42
HDAC8 Q9BY41 3/20 0.42
HDAC5 Q9UQL6 2/20 0.42
HDAC3 O15379 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14917873 1.00 HDAC4 (0.49) HDAC4HDAC6TAS1R3TAS1R1HDAC1
SCHEMBL446155 0.83 TAS1R3 (0.52) HDAC6TAS1R3TAS1R1HDAC1HDAC3
SCHEMBL14918460 0.82 HDAC4 (0.54) HDAC4HDAC6TAS1R3TAS1R1HDAC1
SCHEMBL14918464 0.82 HDAC4 (0.54) HDAC4HDAC6TAS1R3TAS1R1HDAC1
SCHEMBL4252461 0.81 TAS1R3 (0.50) TAS1R3TAS1R1
SCHEMBL14917962 0.76 HDAC4 (0.47) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14917963 0.76 HDAC4 (0.47) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14917965 0.76 HDAC4 (0.47) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14917964 0.76 HDAC4 (0.47) HDAC4HDAC6HDAC1HDAC8HDAC5
SCHEMBL14918133 0.74 HDAC4 (0.47) HDAC4HDAC6TAS1R3TAS1R1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013066833-A1 COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES GLAXOSMITHKLINE LLC (US) 2013-05-10 WO claimed
WO-2013066833-A1 COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed