Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11288 | 0.93 | — | — | |
| Acetic Acid SCHEMBL1034775 | 0.91 | CRBN (0.44) | MAP3K14CRBNMEN1APEX1KMT2A | |
| SCHEMBL7530545 | 0.91 | MAP3K14 (0.41) | MAP3K14CRBNMEN1APEX1KMT2A | |
| Carbamic Acid SCHEMBL2782197 | 0.91 | MEN1 (0.42) | MAP3K14CRBNMEN1APEX1KMT2A | |
| Ammonia Solution, Strong SCHEMBL25176856 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL3986242 | 0.90 | — | — | |
| Phosphine SCHEMBL22345181 | 0.90 | — | — | |
| SCHEMBL31244467 | 0.90 | — | — | |
| SCHEMBL320576 | 0.90 | — | — | |
| Acetone SCHEMBL28868967 | 0.88 | MAP3K14 (0.43) | MAP3K14CRBNMEN1APEX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114438048-B | Urate oxidase preparation and application thereof | 重庆派金生物科技有限公司 | 2024-10-22 | — | — | CN | claimed |
| CN-118497161-A | Polyethylene glycol modified urate oxidase | 重庆派金生物科技有限公司 | 2024-08-16 | — | — | CN | claimed |
| CN-117866929-A | Pegylated arginine deiminase dimer preparation and use thereof | 重庆派金生物科技有限公司 | 2024-04-12 | — | — | CN | claimed |
| CN-114438048-A | Urate oxidase preparation and application thereof | 重庆派金生物科技有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-111909906-A | Urate oxidase modified by polyethylene glycol | 重庆派金生物科技有限公司 | 2020-11-10 | — | — | CN | claimed |
| WO-1996021469-A1 | MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES | SHEARWATER POLYMERS, INC. (US) | 1996-07-18 | — | — | WO | claimed |
| CN-119970617-A | Improved coupling joint | 普罗林科斯有限责任公司 | 2025-05-13 | — | — | CN | disclosed |
| CN-114438048-B | Urate oxidase preparation and application thereof | 重庆派金生物科技有限公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-118497161-A | Polyethylene glycol modified urate oxidase | 重庆派金生物科技有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-111909906-B | Polyethylene glycol modified urate oxidase | 重庆派金生物科技有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-117866929-A | Pegylated arginine deiminase dimer preparation and use thereof | 重庆派金生物科技有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-117098811-A | High flux microemulsified membrane | 普罗林科斯有限责任公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114585397-A | Steam sterilization of hydrogels crosslinked by beta-elimination of linkers | 普罗林科斯有限责任公司 | 2022-06-03 | — | — | CN | disclosed |
| US-5270384-A | Surface-modified polyacrylonitrile fibrous substrates | AMERICAN CYANAMID COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5268421-A | Surface-modified polyacrylonitrile beads | AMERICAN CYANAMID COMPANY (US) | 1993-12-07 | — | — | US | disclosed |
| US-5194512-A | Surface-modified polyacrylonitrile substrates | AMERICAN CYANAMID COMPANY (US) | 1993-03-16 | — | — | US | disclosed |
| US-5155174-A | With pendant N-haloamide groups | AMERICAN CYANAMID COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| US-5137983-A | Surface-modified polyacrylonitrile beads | AMERICAN CYANAMID COMPANY (US) | 1992-08-11 | — | — | US | disclosed |
| US-5082904-A | Surface-modified polyacrylonitrile substrates | AMERICAN CYANAMID COMPANY (US) | 1992-01-21 | — | — | US | disclosed |
| EP-0397119-A2 | Surface-modified polyacrylonitrile substrates | CYTEC TECHNOLOGY CORP. (US) | 1990-11-14 | — | — | EP | disclosed |