Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918280 | 1.00 | L3MBTL1 (0.48) | L3MBTL1MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL14917904 | 1.00 | L3MBTL1 (0.48) | L3MBTL1MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL14917930 | 0.99 | MAPT (0.49) | L3MBTL1MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL14917853 | 0.96 | MAPT (0.53) | L3MBTL1MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL14918498 | 0.91 | HDAC6 (0.52) | L3MBTL1MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL14918820 | 0.89 | HDAC1 (0.52) | HDAC1HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL14918334 | 0.89 | HDAC1 (0.52) | HDAC1HDAC8HDAC6KMT2AMEN1 | |
| SCHEMBL14918039 | 0.89 | MEN1 (0.59) | L3MBTL1MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL14918677 | 0.89 | MEN1 (0.59) | L3MBTL1MAPTHDAC1HDAC8HDAC6 | |
| SCHEMBL14917901 | 0.89 | MEN1 (0.59) | L3MBTL1MAPTHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| US-8871770-B2 | Carboxamide compounds and methods for using the same | MIDCAP FINANCIAL TRUST | 2014-10-28 | — | — | US | disclosed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |