⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1681639 | 0.78 | — | — | |
| SCHEMBL13692 | 0.76 | — | — | |
| SCHEMBL3392039 | 0.76 | KDM4E (0.50) | — | |
| SCHEMBL14157901 | 0.76 | TRPV1 (0.46) | — | |
| SCHEMBL8899967 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL6489775 | 0.73 | — | — | |
| SCHEMBL82871 | 0.73 | — | — | |
| SCHEMBL24158347 | 0.73 | — | — | |
| SCHEMBL4278579 | 0.72 | KDM4E (0.44) | — | |
| SCHEMBL8008558 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 303 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421533-B1 | NOVEL ANTI-INFLAMMATORY AGENTS | RESVERLOGIX CORP (CA) | 2018-10-17 | — | — | EP | claimed |
| US-9757368-B2 | Anti-inflammatory agents | RESVERLOGIX CORP. (CA) | 2017-09-12 | — | — | US | claimed |
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | claimed |
| US-20130281398-A1 | TREATMENT OF DISEASES BY EPIGENETIC REGULATION | RVX THERAPEUTICS INC. (CA) | 2013-10-24 | — | — | US | claimed |
| EP-1951686-B1 | QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM IND CO LTD (KR) | 2013-04-03 | — | — | EP | claimed |
| US-8354448-B2 | Use of (−)(3-trihalomethylphenoxy)(4-halophenyl) acetic acid derivatives for treatment of type 2 diabetes | METABOLEX, INC. (US) | 2013-01-15 | — | — | US | claimed |
| US-8329749-B2 | Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of hyperuricemia | METABOLEX, INC. (US) | 2012-12-11 | — | — | US | claimed |
| US-20120059002-A1 | NOVEL ANTI-INFLAMMATORY AGENTS | HEPALINK (HONG KONG) LIMITED (HK) | 2012-03-08 | — | — | US | claimed |
| EP-2421533-A1 | NOVEL ANTI-INFLAMMATORY AGENTS | RESVERLOGIX CORP. (CA) | 2012-02-29 | — | — | EP | claimed |
| US-7872028-B2 | Diaminopropanol renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2011-01-18 | — | — | US | claimed |
| EP-0254032-A2 | Neutral metalloendopeptidase inhibitors in the treatment of hypertension | SCHERING CORPORATION (US) | 1988-01-27 | — | — | EP | claimed |
| US-4680392-A | Substituted caprolactam derivatives as antihypertensives | MERCK & CO., INC. (US) | 1987-07-14 | — | — | US | claimed |
| EP-0227818-A1 | ANTIGLAUCOMA COMPOSITIONS. | SCHERING CORP (US) | 1987-07-08 | — | — | EP | claimed |
| WO-1987000055-A1 | ANTIGLAUCOMA COMPOSITIONS | SCHERING CORPORATION (US) | 1987-01-15 | — | — | WO | claimed |
| US-4622407-A | Resolution of racemic derivatives of 5-(1-methyl-5-methylthiopyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-2-carboxylic acid and analogs | MERCK & CO., INC. (US) | 1986-11-11 | — | — | US | claimed |
| US-4587050-A | Substituted enantholactam derivatives as antihypertensives | MERCK & CO., INC. (US) | 1986-05-06 | — | — | US | claimed |
| EP-0159674-A2 | Resolution of racemic derivatives of 5-(1-methyl-5-methyl-thiopyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-2-carboxylic acid and analogs | MERCK & CO. INC. (US) | 1985-10-30 | — | — | EP | claimed |
| US-4536512-A | 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2,3-dihydro-1H-pyrrolizine-1-alkanoic or carboxylic acids and use thereof as anti-inflammatory and analgesic agents | MERCK & CO., INC. (US) | 1985-08-20 | — | — | US | claimed |
| US-4533671-A | 5-(2,3-Dihydro-1H-pyrrolizin-5-oyl)-2-alkanoic or carboxylic acids and analogs as anti-inflammatory and analgesic agents | MERCK & CO., INC. (US) | 1985-08-06 | — | — | US | claimed |
| EP-0096816-A2 | New 5-(pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole derivatives as anti-inflammatory and analgesic agents | MERCK & CO. INC. (US) | 1983-12-28 | — | — | EP | claimed |