Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 10/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
| ▸ | SLC6A7 | Q99884 | 6/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918456 | 0.88 | HDAC4 (0.55) | HDAC4HDAC6HDAC8HDAC2MGLL | |
| SCHEMBL2226604 | 0.83 | SLC6A7 (0.62) | HDAC4HDAC6HDAC8HDAC2MGLL | |
| SCHEMBL14645510 | 0.83 | HDAC4 (1.00) | HDAC4HDAC6HDAC8HDAC2MGLL | |
| SCHEMBL14932826 | 0.80 | HDAC4 (0.68) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL14918156 | 0.80 | SMN1; SMN2 (0.53) | HDAC4HDAC6HDAC8ALDH1A1HSD11B1 | |
| SCHEMBL2223478 | 0.80 | HDAC4 (0.58) | HDAC4HDAC6HDAC8HDAC2MGLL | |
| SCHEMBL14932814 | 0.79 | HDAC4 (0.65) | HDAC4HDAC6HDAC8HDAC2 | |
| Trifluoroacetic Acid SCHEMBL14918037 | 0.78 | HDAC6 (0.48) | HDAC4HDAC6HDAC8HDAC2 | |
| SCHEMBL2227129 | 0.78 | HDAC4 (0.71) | HDAC4HDAC6HDAC8HDAC2MGLL | |
| SCHEMBL2223611 | 0.77 | HDAC4 (0.59) | HDAC4HDAC6HDAC8HDAC2SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |
| WO-2013066831-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |