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SLC6A7

Sodium-dependent proline transporter · Q99884 · SLC6A7 on Sugi Atlas →

13,893 patent compounds predicted against SLC6A7, 8,162 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL694421 SCHEMBL694421 0.74 19/20
SCHEMBL95079 SCHEMBL95079 0.72 17/20
SCHEMBL220133 SCHEMBL220133 0.72 17/20
SCHEMBL867597 SCHEMBL867597 0.54 15/20
SCHEMBL1135093 SCHEMBL1135093 0.68 13/20
SCHEMBL911909 SCHEMBL911909 0.60 10/20
SCHEMBL912559 SCHEMBL912559 0.60 10/20
SCHEMBL798246 SCHEMBL798246 0.58 10/20
SCHEMBL912187 SCHEMBL912187 0.52 7/20
SCHEMBL911058 SCHEMBL911058 0.51 7/20
SCHEMBL911989 SCHEMBL911989 0.51 7/20
SCHEMBL911161 SCHEMBL911161 0.49 7/20
SCHEMBL912001 SCHEMBL912001 0.58 6/20
SCHEMBL868055 SCHEMBL868055 0.58 6/20
SCHEMBL911744 SCHEMBL911744 0.48 6/20
SCHEMBL911970 SCHEMBL911970 0.59 5/20
SCHEMBL720267 SCHEMBL720267 0.56 5/20
SCHEMBL1222665 SCHEMBL1222665 0.55 5/20
SCHEMBL713524 SCHEMBL713524 0.52 5/20
Tt-301 Tt-301 (SCHEMBL529969) 0.51 5/20

Clinical trials — most relevant to SLC6A7 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD PHASE3COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia PHASE1/PHASE2RECRUITING
Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin PHASE2NOT_YET_RECRUITING
DAAOI-1 Treatment for Treatment-resistant Schizophrenia PHASE2COMPLETED
Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors PHASE1RECRUITING
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters EARLY_PHASE1COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer EARLY_PHASE1UNKNOWN
Oxalate and Citrate in Humans - Response to Citrate nanRECRUITING
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting nanUNKNOWN
Additional Dietary Large Neutral Amino Acids (LNAA) for Improved Symptoms in Adult Classical Phenylktonuria (PKU) nanUNKNOWN
Observational Study of the Impact of Genetic Testing on Healthcare Decisions and Care in Interventional Pain Management nanUNKNOWN
Molecular Epidemiology of Essential Hypertension nanCOMPLETED
Evaluation of Renal Function in Patients With Hyperthyroidism nanNOT_YET_RECRUITING
Study of CYP2C19 and ALDH3A1 Polymorphisms in Breast Cancer Patients nanUNKNOWN
Autonomic Function in Patients With COPD nanCOMPLETED
Insulin Detemir in Obesity Management nanACTIVE_NOT_RECRUITING
Brain P-gp and Inflammation in People With Epilepsy nanCOMPLETED
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs nanCOMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts nanCOMPLETED
Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients nanUNKNOWN
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS nanCOMPLETED
I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers nanCOMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS nanNOT_YET_RECRUITING
Childhood Adversity, Genetic Polymorphisms and Stress in First Onset Major Depression nanCOMPLETED
Estrogen Receptor 1 Gene Polymorphism Frequency in Fibromyalgia Syndrome nanCOMPLETED
Erythrocyte Transport of Lactate During Exercise (TELE Project) nanRECRUITING
Stem Cell Study of Genetics and Drug Addiction nanCOMPLETED
Using Cotyledon Perfusion to Study Drugs Transfer Across the Placenta nanRECRUITING
A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a SLC6A7 binder may also engage these)

ProteinNameSimilarity
Q6PGE7 — 0.999 Q6PGE7 →
SLC6A13 Sodium- and chloride-dependent GABA transporter 2 0.998 landscape →
P31661 — 0.998 P31661 →
P31649 — 0.998 P31649 →
P28573 — 0.998 P28573 →
O18875 — 0.997 O18875 →
P28570 — 0.997 P28570 →
P31651 — 0.997 P31651 →
P48056 — 0.997 P48056 →
P31646 — 0.997 P31646 →
Q61327 — 0.997 Q61327 →
P23977 — 0.997 P23977 →
Q9MZ34 — 0.996 Q9MZ34 →
P48055 — 0.996 P48055 →
Q96N87 — 0.996 Q96N87 →
Q2PG55 — 0.995 Q2PG55 →
P28572 — 0.995 P28572 →
O88575 — 0.995 O88575 →
P48029 — 0.995 P48029 →
P51143 — 0.995 P51143 →
A5PJX7 — 0.995 A5PJX7 →
SLC6A4 Sodium-dependent serotonin transporter 0.995 landscape →
P27799 — 0.994 P27799 →
Q8VBW1 — 0.994 Q8VBW1 →
Q91502 — 0.994 Q91502 →
SLC6A12 Sodium- and chloride-dependent betaine transporter 0.994 landscape →
Q28039 — 0.994 Q28039 →
Q9GJT6 — 0.994 Q9GJT6 →
Q00589 — 0.993 Q00589 →
P31652 — 0.993 P31652 →