Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 17/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918350 | 0.89 | HDAC4 (0.37) | HDAC4HDAC6HDAC1HDAC8 | |
| SCHEMBL14918288 | 0.89 | HDAC4 (0.36) | HDAC4HDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL14917921 | 0.89 | HDAC6 (0.36) | HDAC4HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL14917945 | 0.87 | HDAC4 (0.36) | HDAC4HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL14918015 | 0.87 | HDAC8 (0.36) | HDAC4HDAC6HDAC1HDAC8HDAC5 | |
| SCHEMBL14918088 | 0.86 | HDAC1 (0.37) | HDAC4HDAC6HDAC1HDAC8HDAC2 | |
| SCHEMBL14917977 | 0.83 | HDAC4 (0.35) | HDAC4HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL14918446 | 0.82 | HDAC1 (0.36) | HDAC4HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL14917790 | 0.79 | HDAC6 (0.37) | HDAC4HDAC6HDAC1HDAC8HDAC3 | |
| SCHEMBL14918042 | 0.79 | L3MBTL1 (0.36) | HDAC4HDAC6HDAC1HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |