Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KYAT1 | Q16773 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 8/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491865 | 1.00 | KYAT1 (0.60) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL26711821 | 1.00 | KYAT1 (0.60) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL19384340 | 0.93 | KYAT1 (0.64) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL19398368 | 0.89 | KYAT1 (0.60) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL11390894 | 0.88 | KYAT1 (0.58) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL11390921 | 0.88 | KYAT1 (0.58) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL15047055 | 0.87 | NPSR1 (0.48) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL15047081 | 0.87 | NPSR1 (0.48) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL1491860 | 0.86 | MEN1 (0.61) | KYAT1GAAATMMAPTRAB9A | |
| SCHEMBL19283212 | 0.86 | MAPT (0.56) | KYAT1GAAATMMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130029983-A1 | AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-01-31 | — | — | US | disclosed |
| WO-2011037985-A1 | AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029983-A1 | AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY | MAPT, PSEN1, PSEN2 | KYAT1 2515/4885GAA 1432/4885ATM 3466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.