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Sugi Predict / Targets / KYAT1

KYAT1

Kynurenine--oxoglutarate transaminase 1 · Q16773 · KYAT1 on Sugi Atlas →

2,161 patent compounds predicted against KYAT1, 1,338 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2998450 SCHEMBL2998450 0.64 6/20
SCHEMBL4104434 SCHEMBL4104434 0.61 6/20
SCHEMBL5253472 SCHEMBL5253472 0.51 6/20
SCHEMBL5253476 SCHEMBL5253476 0.51 6/20
SCHEMBL5845056 SCHEMBL5845056 0.50 6/20
SCHEMBL393794 SCHEMBL393794 0.49 6/20
SCHEMBL7041159 SCHEMBL7041159 0.47 6/20
SCHEMBL3560755 SCHEMBL3560755 0.64 5/20
SCHEMBL3560757 SCHEMBL3560757 0.64 5/20
SCHEMBL6303636 SCHEMBL6303636 0.62 5/20
SCHEMBL1491863 SCHEMBL1491863 0.60 5/20
SCHEMBL1491865 SCHEMBL1491865 0.60 5/20
SCHEMBL6740052 SCHEMBL6740052 0.48 5/20
SCHEMBL6740055 SCHEMBL6740055 0.48 5/20
SCHEMBL5843881 SCHEMBL5843881 0.45 5/20
Glutarate Glutarate (SCHEMBL3866346) 0.43 5/20
SCHEMBL6156730 SCHEMBL6156730 0.40 5/20
SCHEMBL6156734 SCHEMBL6156734 0.40 5/20
SCHEMBL6156735 SCHEMBL6156735 0.40 5/20
SCHEMBL6416432 SCHEMBL6416432 0.37 5/20

Clinical trials — most relevant to KYAT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The Role of CYP8B1 Polymorphisms in Modulating the Biochemical Pathways Affected by SGLT2 Inhibitors in T2DM and Obesity PHASE4COMPLETED
Folate Rechallenge PHASE2COMPLETED
Effects of Febuxostat for Lowering Uric Acid in NAFLD Patients With Gout PHASE2UNKNOWN
Prevention of Acute Myocardial Injury by Trimetazidine in Patients Hospitalized for COVID-19 PHASE2UNKNOWN
A Phase Ib/II Clinical Study of AK127 in Combination With AK112 in Patients With Advanced Solid Tumors PHASE1/PHASE2ACTIVE_NOT_RECRUITING
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Diclofenac Dose Response Study PHASE1RECRUITING
A Study of AK146D1 for Injection in Advanced Solid Tumors PHASE1RECRUITING
A Study of AK146D1 for Injection in the Treatment of Advanced Solid Tumors PHASE1RECRUITING
Mitochondrial Assessment in Critical Ill Patients in Intensive Care nanNOT_YET_RECRUITING
Androgens and NAFLD Longitudinal Cohort Study nanRECRUITING
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU) nanRECRUITING
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia nanRECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Evaluation of Hydroxymethylbutyrate Supplementation in Lung Transplant Candidates Receiving Pulmonary Rehabilitation nanCOMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population nanUNKNOWN
Lysine Oxidation in Response to Arginine Supplementation nanCOMPLETED
Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults nanCOMPLETED
Alternative Substrates in the Critically Ill Subject nanCOMPLETED
11C-Acetate PET/CT Non-FDG-Avid Tumors nanUNKNOWN
Screening of IDH1 and IDH2 Gene Mutations in Adult Acute Myeloid Leukemia for Possible Targeted Therapy nanUNKNOWN
Effect of Branched Chain Amino Acids on Muscle nanCOMPLETED
Genetic-specific Effects of Fructose on Liver Lipogenesis nanCOMPLETED
Therapeutic Ketogenic Diet in Anorexia Nervosa nanRECRUITING
Diabetic Cardiomyopathy and Heart Failure nanWITHDRAWN
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism nanCOMPLETED
Clinical Trials of Five Different Food Supplements With Restriction Diet in Adults nanCOMPLETED
Epidemiology of Atherosclerosis nanCOMPLETED
Effect of Increased Physical Activity and Stopping Evening Snacking in Metabolic Health in Youth With Prediabetes nanRECRUITING
The Intervention Study of Dietary Intake on Energy Expenditure nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a KYAT1 binder may also engage these)

ProteinNameSimilarity
Q8BTY1 — 0.994 Q8BTY1 →
Q08415 — 0.987 Q08415 →
Q7T3E5 — 0.984 Q7T3E5 →
Q71RI9 — 0.983 Q71RI9 →
Q58FK9 — 0.979 Q58FK9 →
Q0P5G4 — 0.979 Q0P5G4 →
Q9STR4 — 0.974 Q9STR4 →
Q5E9N4 — 0.972 Q5E9N4 →
AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 0.971 landscape →
P37821 — 0.971 P37821 →
Q9SAR0 — 0.969 Q9SAR0 →
KYAT3 Kynurenine--oxoglutarate transaminase 3 0.968 landscape →
Q17CS8 — 0.968 Q17CS8 →
Q8BGT5 — 0.968 Q8BGT5 →
Q64602 — 0.967 Q64602 →
Q01912 — 0.966 Q01912 →
Q7XQ85 — 0.965 Q7XQ85 →
Q9MB95 — 0.965 Q9MB95 →
P31531 — 0.964 P31531 →
Q9FN30 — 0.964 Q9FN30 →
Q58CZ9 — 0.963 Q58CZ9 →
O54695 — 0.962 O54695 →
Q9M2Y8 — 0.962 Q9M2Y8 →
Q6GM82 — 0.962 Q6GM82 →
P17735 — 0.962 P17735 →
Q3MHG1 — 0.962 Q3MHG1 →
Q37001 — 0.961 Q37001 →
O35704 — 0.961 O35704 →
Q9LVY1 — 0.961 Q9LVY1 →
P18485 — 0.960 P18485 →