Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918183 | 0.78 | HDAC4 (0.62) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL445904 | 0.78 | HRH3 (0.54) | HDAC1HRH3HRH2HRH1 | |
| SCHEMBL14918046 | 0.77 | HDAC4 (0.60) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL4249319 | 0.76 | HRH3 (0.53) | HRH3KDM4EHRH2HRH1 | |
| SCHEMBL14918645 | 0.75 | HDAC4 (0.59) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL14917713 | 0.73 | HDAC4 (0.71) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL14917776 | 0.73 | HDAC4 (0.63) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL14918098 | 0.73 | HDAC6 (0.62) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL14917705 | 0.73 | HDAC4 (0.65) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL14917704 | 0.73 | HDAC4 (0.65) | HDAC6HDAC1HDAC4HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066833-A1 | COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066833-A1 | COMPOUNDS AND METHODS TO INHIBIT HISTONE DEACETYLASE (HDAC) ENZYMES | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |