Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14918566 | 0.96 | HDAC6 (0.41) | HDAC6HDAC1HDAC8LMNAMAPT | |
| SCHEMBL14918852 | 0.95 | HDAC1 (0.40) | HDAC6HDAC1HDAC8LMNAMAPT | |
| SCHEMBL14918996 | 0.95 | HDAC1 (0.40) | HDAC6HDAC1HDAC8LMNAMAPT | |
| SCHEMBL14918434 | 0.95 | HDAC1 (0.40) | HDAC6HDAC1HDAC8LMNAMAPT | |
| SCHEMBL14918963 | 0.93 | HDAC6 (0.43) | HDAC6HDAC1HDAC8LMNAMAPT | |
| SCHEMBL14918538 | 0.86 | LMNA (0.56) | HDAC6HDAC1HDAC8LMNAUSP2 | |
| SCHEMBL14918878 | 0.83 | HDAC6 (0.48) | HDAC6HDAC1HDAC8LMNAMAPT | |
| SCHEMBL14918429 | 0.83 | HDAC4 (0.54) | HDAC6HDAC1HDAC8LMNAUSP2 | |
| SCHEMBL14918877 | 0.82 | HDAC4 (0.56) | HDAC6HDAC1HDAC8LMNAUSP2 | |
| SCHEMBL14918567 | 0.82 | HDAC4 (0.56) | HDAC6HDAC1HDAC8LMNAUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | claimed |
| WO-2013066836-A1 | COMPOUNDS AND METHODS | GLAXOSMITHKLINE LLC (US) | 2013-05-10 | — | — | WO | disclosed |