SCHEMBL14918783

SCHEMBL14918783

O=C(CCc1noc(C(F)(F)F)n1)Nc1cnccn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 7/20 0.46
HDAC1 Q13547 3/20 0.46
HDAC8 Q9BY41 3/20 0.46
HDAC4 P56524 5/20 0.41
ALOX15 P16050 1/20 0.40
TSHR P16473 1/20 0.40
CASP1 P29466 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HSD17B10 Q99714 1/20 0.40
NPC1 O15118 1/20 0.38
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
NFKB1 P19838 1/20 0.38
RAB9A P51151 1/20 0.38
NFKB2 Q00653 1/20 0.38
RELA Q04206 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
NOTUM Q6P988 1/20 0.37
KMT2A Q03164 2/20 0.36
DYRK3 O43781 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14919093 0.93 HDAC6 (0.44) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14919137 0.92 HDAC6 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918553 0.91 HDAC1 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918779 0.91 HDAC1 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918655 0.91 HDAC1 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918438 0.84 GAA (0.49) HDAC6HDAC1HDAC8HDAC4HSD17B10
SCHEMBL14918729 0.83 HDAC4 (0.40) HDAC6HDAC1HDAC4TRPV1
SCHEMBL14918892 0.81 HDAC4 (0.57) HDAC6HDAC1HDAC8HDAC4NPC1
SCHEMBL14917800 0.80 HDAC6 (0.41) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918963 0.80 HDAC6 (0.43) HDAC6HDAC1HDAC8HDAC4NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013066836-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO claimed
WO-2013066836-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed