SCHEMBL14919093

SCHEMBL14919093

O=C(CCCc1noc(C(F)(F)F)n1)Nc1cnccn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 6/20 0.44
HDAC1 Q13547 2/20 0.44
HDAC8 Q9BY41 2/20 0.44
HDAC4 P56524 4/20 0.40
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38
CASP1 P29466 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD17B10 Q99714 1/20 0.38
DYRK3 O43781 3/20 0.37
PRKD3 O94806 3/20 0.37
MAP4K4 O95819 3/20 0.37
CDK2 P24941 3/20 0.37
CLK2 P49760 3/20 0.37
GSK3B P49841 3/20 0.37
LIMK1 P53667 3/20 0.37
CDK5 Q00535 3/20 0.37
DYRK1A Q13627 3/20 0.37
BRSK1 Q8TDC3 3/20 0.37
CLK4 Q9HAZ1 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14919137 0.97 HDAC6 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918553 0.96 HDAC1 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918779 0.96 HDAC1 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918655 0.96 HDAC1 (0.43) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918783 0.93 HDAC6 (0.46) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918743 0.84 ALDH1A1 (0.56) HDAC6HDAC1HDAC8HDAC4MAPT
SCHEMBL14918808 0.83 HDAC4 (0.39) HDAC6HDAC1HDAC8HDAC4MAPT
SCHEMBL14917800 0.82 HDAC6 (0.41) HDAC6HDAC1HDAC8HDAC4ALOX15
SCHEMBL14918538 0.81 LMNA (0.56) HDAC6HDAC1HDAC8HDAC4NPC1
SCHEMBL14918554 0.81 HDAC1 (0.53) HDAC6HDAC1HDAC8HDAC4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013066836-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO claimed
WO-2013066836-A1 COMPOUNDS AND METHODS GLAXOSMITHKLINE LLC (US) 2013-05-10 WO disclosed